asthma

Feeling wheezy? HRT may be that albatross around your neck…

Posted by Liz on Sep 10, 2012 in asthma | 0 comments

Did you know that asthma affects an estimated 300 million people across the globe? That’s roughly one in 20 and it’s incidence is expected to rise over the next few years, especially in urban areas. However, did you also realize that researchers believe that there may be a connection between reproductive status, reproductive hormones and the development of asthma? In fact, while early on, asthma occurs in greater rates among boys than girls, this flips in puberty and by the time early adulthood hits, twice as many women as men suffer from asthma. As women start to age, however, the role of hormones is less clear, with some research showing that asthma rates decline through natural menopause, early or surgical menopause may be associated with greater risk.

Despite an extensive review of available studies, the evidence for the link between asthma and menopause remains limited, except among women who experienced early menopause and started using hormonal therapy. Take note that while this increased risk was minimal, it is in direct conflict with reports that claim that hormone therapy actually protects against asthma! Indeed, it is believed that  low levels of estrogen may act to protect against the development of asthma while abnormally high levels, such as those created by exogenous hormones, can increase it. And it’s not the first time that I’ve come across this link (check out these earlier posts!). Additionally, it may be possible that women who go through early menopause may have hormonal imbalances that are linked to respiratory issues and illness.

Still, the association is unclear and it’s likely to factors other than gender and hormones also play a role in asthma, such as genetics and metabolism. In the meantime? Be mindful that replacing estrogen may not be the most natural pathway and perhaps, its decline, despite being associated with a myriad of troublesome symptoms like flashes, sweats and swings, is also protective.

If you are feeling wheezy and don’t take hormones, it’s probably not the ‘pause. If you are on hormone replacement and notice changes in your breathing, take pause and get yourself in to see a practitioner.

Breathe. What you need to know about asthma and HRT

Posted by Liz on Sep 30, 2011 in asthma, HRT, menopause | 0 comments

If you suffer from asthma, you will want to take note: researchers presenting at this week’s European Respiratory Society AnnualConference have shown that female asthmatics have an increased risk of landing in the hospital if they take hormone replacement therapy (HRT). Yet another nail in the HRT coffin, once again demonstrating that the health risks of taking hormone replacement may outweigh the benefits.

Notably, studies have shown that asthma risk increases in women after puberty. Moreover, hormones, most specifically fluctuating estrogen levels, can impact airways as much as allergies and hay fever (fluctuating estrogen levels can produce an inflammatory response and exacerbate breathing difficulties). On average, asthma symptoms develop in about 21% of menopausal women and more than twice as many using hormone therapy.

In this study of over 23,000 Danish women with documented asthma, researchers looked specifically at hospitalizations for severe reactions. They also collected information on smoking, exposure to smoke, body mass index, level of physical activity, history of hysterectomy and use of HRT.  The findings? Using HRT increased the risk for hospitalization for severe asthma reactions by as much as 40% compared to not using hormone therapy. What’s more, the longer the women used HRT, the higher their risk of ending up in the hospital; for example, if they used it for less than 3 years, they have a 29% increased risk and if they used it for more than 10, a 51% increased risk. Even more troubling was the fact that women didn’t smoke appeared to have the highest risk for being hospitalized in association with their HRT use.

Although this isn’t a randomized trial, and more information is needed, the researchers still recommend that practitioners be made aware of these findings. They say that the relationship between asthma and female sex hormones is hardly new, but that their findings confirm the relationship and further our understanding of it by showing the extent of severe asthma reactions that occur when women take hormones. “If a patient develops asthma or has a severe worsening of symptoms after taking HRT, they may need to stop hormone therapy altogether,” they add.

Unchain my lungs…estrogen and asthma

Posted by Liz on Feb 12, 2010 in asthma, estrogen, HRT | 2 comments

As the evidence continues to accrue against the use of combined hormone replacement therapy (HRT), attention must be turned to estrogen-only hormone replacement therapy. However, is it safer?

In the Women’s Health Initiative, which was halted last decade, taking estrogen alone was associated with an increased risk of blood clots, stroke, impaired cognitive function and dementia. In the latest bit of information to hit the news, estrogen-only therapy may also increase the risk for developing asthma.

Results of a 12-year study among almost 58,000 women who were not suffering from asthma at the start of menopause showed that they were 21% more likely to develop asthma symptoms. This risk was significant among women who had been taking estrogen only compared to women who had never used hormones, had a 54% greater risk of developing asthma. The risk was even greater among women who had never smoked, although a small proportion of study participants had allergies prior to developing asthma.

Once again, Reuters has done an excellent job of reporting on this study and has some great quotes from the researchers as well.

Meanwhile, what should you do if you’ve been taking estrogen to combat the symptoms of menopause? As always, you have a choice and only you and your practitioner can determine if you are at risk for developing any of the conditions that are associated with hormonal therapy. The good news? Breathe easy. Yet another reason to lose the hormones…for good.