This past weekend I was discussing the issue of my growing forgetfulness with a friend who, like me, appears to be losing her mind at times. Later that day, upon I landing at a local airport, I realized that I had forgotten where I parked my car only two days earlier. To add insult to injury? I had used a parking app so that I could remember. Only, it took a few minutes before I remembered that I had used the app.
Memory lapse is common among women as they transition from premenopause to perimenopause to full menopause, and even appears to cross boundaries and cultures. In the years that I’ve been writing Flashfree, I have run across data linking memory loss to stress, hormones and even a decline in gray brain matter. (If you would like to check out these posts, you can find them here.) Apparently, hot flashes have also been shown to be a significant predictor of so-called forgetfulness. In one study in particular, women were found to experience more memory problems and cognitive issues when they experienced more frequent hot flashes and sweats. Additionally the intensity of those flashes were directly correlated to how long memory issues lasted.
This probable link has been teased out recently in a small (68) pool of midlife women who reported having at least 35 hot flashes a week. Importantly, data were not only based on recall but also, on scientific measures of cognitive functioning (ability to remember words after both short and long delays), menopausal symptoms, sleep and positive and negative moods. With regard to memory in particular, the women were scored on how often they forgot, how serious a failing memory was in those situations, current memory in relation to earlier events in their lives (e.g. 5 years ago, 10 years ago) and the frequency with which they used or didn’t use memory aids. They were also asked to rate their current memory.
One of the most interesting findings was the validation that objective memory performance predicted the magnitude of subjective memory, i.e. the women had an accurate idea of how well or poorly their memory was functioning. What’s more, the higher the numbers of self-reported vasomotor symptoms, the more women recalled having issues in the past, which suggests that women with more vasomotor symptoms — more flashes and sweats — experienced cognitive issues longer than women with fewer symptoms. And, the greater the degree of negative mood — depression, anxiety, hostility — the higher the frequency of forgetting, again, confirming that complaints of memory loss during menopause is not, to coin a phrase, all in your head!
We still lack information on how the relationship between what we believe happens to our memory and what can be measured or confirmed changes as we age or across different menopausal stages. However, the data lend credence to claims that memory is changing during menopause, especially in terms of performance on tasks, and that our mood can influence how well we comprehend or judge the severity and seriousness of those lapses.
Feel like you are losing your mind at times? If you are in the throes of the ‘pause, this feeling may not be going away any time soon.
If you are at all like me, chances are that you talk to yourself. I credit this self talk to the fact that I work at home, alone in my office, save for a couple of cats, phone calls and the constant of my virtual connections. And while some may think that this constant chatter doesn’t serve much of a purpose, it appears that it might be the ticket to locating a particular object while also insuring that you actually remember what you are looking for!
In fact, this theory runs counter to commonly held beliefs that languasimply simply a tool for communicating ined.and does not affect thought or concepts. University of Wisconsin Researcher Gary Lupyan argues that language and words can change concepts and perception.
He and his colleagues came to this conclusion after running several experiments to learn if self-directed speech, i.e. repeating the name of an object being sought, would make the search faster and and more efficient. To achieve this, participants were asked find one or more objects, either by speaking the name of it (or them) before or during a search, or reading it’s name without speaking it out loud.
It’s interesting because what they learned was that if the target object was familiar and something that evoked an image when spoken aloud (like banana), then the search was easier.
But, if they were searching for a less or unfamiliar object, saying the name of it repeatedly did not appear to have much of an effect.
The researchers say that speech does affect search and in fact, activates a visual cue that stays top of mind when searching for something. However whether or not it affects how quickly an object can be found is yet to be determined.
Mind you, it’s nice to know that all my self chatter might help to put an end to the memory loss, entering rooms without a clue and even finding lost objects. And that maybe, just maybe, talking to myself is not so bad after all!Read More
Got stress, a lack of focus, too much on your plate? Researchers from the University of Washington report that meditation, namely mindful meditation, can improve focus, benefit memory and reduce stress. What a concept, eh?
Mindfulness meditation is trained meditation. This particular study (reported in the May issue of Proceedings of Graphic Interface) used focused attention, which targets a person’s ability to voluntarily narrow or widen focus, place attention on the present moment, shift focus from one thing to another, and cultivate awareness of breathing and the body. While one group of workers participated in this type of activity, another were actively trained in progressive relaxation, whereby muscle groups are tensed and then relaxed, aided by mental imagery (e.g. “my arms are becoming heavy and warm) , an audio CD and weekly classes. Both of these groups then engaged in multitasking (e.g. scheduling a meeting, finding a conference room, writing an announcement, creating an agenda or eating and drinking). A third group waited 8 weeks, underwent multasking and then were trained in mindful meditation and retested.
The findings? People who were trained in and practiced mindfulness meditation reported lower stress levels during multitasking, were less negative and had less fatigue. Similarly, the group who received mindfulness training later in the study also reported reductions in their stress levels. What’s more, mindfulness meditation also appeared to improve focus (the participants shifted their attention less during a particular task) and memory.
The researchers attribute these benefits to the ability of mindfulness meditation training to help strengthen our ability to notice interruptions without necessarily stopping or diverting attention from the task at hand. Meditation has been associated with enhancing the ability to regular emotions; less stress translates into better recall. This particular domino effect is a win-win-win!
Aging and estrogen. Gotta love it. It can signify the loss of reproduction, skin elasticity, vaginal lubrication, bones and even parts of our brain, at least hypothetically. Yet, can ingesting soy help improve attention, focus, problem solving and memory? A newly published study in Neurology journal counters claims that it can, but adds further evidence that certain factors may influence benefits, such as reproductive age or if menopause comes on naturally or not.
A bit of context is needed. We know that soy isoflavones, primarily genistein, daidzein and glycitein have been suggested as an effective strategy for combating menopausal symptoms such as hot flashes or night sweats. The beneficial effects of soy are believed to be associated with the ability to soy isoflavones to attach themselves to estrogen receptors. Importantly, our brains contain certain estrogen receptors in hippocampus, which is responsible for consolidating both short and long-term memory and spatial navigation. Moreover, both genistein and daidzein have been shown to have a particular affinity for the very type of estrogen receptors that reside in the hippocampus, which is why researchers have been so interested in determining if ingesting soy can help combat the natural decline in memory and cognition. While findings have been mixed, some women appear to be better metabolizers of S-equol, which is related to daidzein, produced in the gut and targets estrogen receptors in beneficial ways that other soy isoflavones do not. If you click on the links posted above, you will find a wealth of information on soy and the research that has been done.
In this particular study, healthy, postmenopausal women received either 25 g daily of isoflavone-rich soy protein (more than 3/4 of which contained genistein and daidzein) or milk-protein daily; both were offered in the form of a powder or bar. Over the next two and half years, the participants visited the clinic at various intervals to participate in tests that measure their cognitive skills, including:
- Executive function (working memory, expression, general intelligence), and,
- Verbal learning, verbal memory and visual memory.
Although the women were not required to change anything about their diet, they were asked to refrain from taking soy supplements over the study course.
The findings? Researchers failed to observe any differences in cognitive function between women taking soy and women taking milk protein, even though scores did improve over the two+ year time period. Yet, they did note differences in improvements in visual memory scores, with women in the soy isoflavone group better able to recall faces both immediately and with a short delay compared to their milk protein peers. The group of younger, postmenopausal women in the study did not appear to have any advantages over the older women (note that age range was as broad as 49 to 94 years).
So, what to make of this? Is your brain on soy an improvement? Apparently, not really. What the researchers do say, however, is that surgical menopause may eventually cause a larger decline in cognitive function over time (these group of women actually showed a worsening in cognition regardless of whether or not they took soy). They also note that soybeans contain active constituents other than isoflavones (e.g. lignans) that may boost or detract from isoflavones effect on cognition.
Still, there is a wee bit of a silver lining. Although it’s true that if you are seeking a better functioning brain, you may wish to look elsewhere, a high soy diet can be consumed without fear of any adverse effects on memory skills that are associated with dementia in later life, and may possibly even improve them. The verdict is still out for women who are naturally high S-equol producers. In so far as hot flashes and night sweats? The evidence looks much better.
Estrogen’s a bitch, isn’t it? But who says that the bitch can’t be tamed or at least, kept at bay?!
Do phytoestrogens improve cognitive performance?
This is the first I’ve heard that phytoestrogens, i.e. isoflavones, lignans (a major form of phytoestrogens found in flaxseed and sesame seeds) and coumestans (a type of phytoestrogen found in split peas, pinto beans and lima beans) may help boost attention, executive function and memory. Yet, similar to other alternative strategies, the studies examining these benefits have yielded mixed results. Moreover, a lot of these studies have been based on short-term and not long-term use of phytoestrogens, have failed to determine how these compounds may influence brain function, and have not looked specifically at women undergoing the menopausal transition, at least until now.
This time, researchers took a cohort of women actively involved in the Study of Women’s Health Across the Nation. All 1,677 women who saw the study through to its end were between the ages of 42 and 52, premenopausal, early or late perimenopausal, and naturally or surgically postmenopausal, and were not using hormones. Importantly, this group of women included several ethnic groups, which allowed the researchers to see if phytoestrogens behaved differently depending on ethnicity; they included white, African American, Hispanic, Chinese and Japanese.
- Diet was regularly evaluated and included interviews, open ended questions and specifically, daily intake of four types of isoflavones, four types of lignans and coumesterol, which is the main phytoestrogen in coumestans. In Asian women, soybeans, tofus and soy milk were the main sources of isoflavones while in non-Asian women, soy mik, tofu and meat substitutes (e.g. seitan) were the main sources. Regardless of ethnic group, coffee and tea were the primary sources of lignans, and bean sprouts, the main source of coumestans.
- Cognitive testing was done in the morning and always in the same language for bilingual women. These tests included processing speed, immediate and delayed recall and working memory.
- The study took place over 6 years and women were visited 10 times.
So, what did they learn?
First, phytoestrogens appear to affect cognitive function differently, depending on the type and stage of menopause. For example, Asian women whose diets had high levels of isoflavones tended to process information quicker but only during early perimenopause and postmenopause. Conversely, during the same time, these women had poor recall. Non-Asian women who ate a lot of isoflavones also had poor recall during perimenopause. Moreover, women who ate the most lignans, regardless of ethic group, appeared to have better memories but only during late perimenopause. Overall, coumestans did not appear to influence brain function whatsoever.
It’s all sort of confusing, isn’t it? What’s more, even the researchers admit that the effects, when seen, were quite small. And the distinctions between Asian and non-Asian women? It’s the chicken/egg paradigm: is it dose or DNA? At the end of the day, it’s all bubble burstable because scientists remain unclear as to how phytoestrogens affect the way we process information. It is possible that its due to their antioxidant characteristics, but who knows?
Meanwhile? Despite potential GI tract issues (e.g. gas, bloating, constipation), incorporating higher levels of phytoestrogens into your diet may be a good thing. Your brain on phytoestrogens? Who doesn’t need a little boost?Read More