Search results for soy isoflavones

Newsflash: What’s the latest on soy?

Posted by Liz on Oct 17, 2014 in hot flash | 0 comments

Does it or doesn’t it? That is, does soy  relieve menopausal hot flashes or not?

The evidence has been less than definitive however, researchers now say that trials examining the benefits or lack thereof of soy in attenuating symptoms may have been negatively affected by significant limitations, such as failing to recognize treatment timing and duration on effectiveness, small numbers of women in the studies and wide variations in how much hot flashes were reduced with treatment. And so, they took another look at the data using a new model, one that allows scientists to actually compare different treatments and evaluate the effectiveness of different factors, including dose, duration of treatment and formulations. This is an important method of analysis and one that could truly be considered a game changer. They say that their findings, published online in the British Journal of Pharmacology, will provide “information for deeper understanding of the efficacy of soy isoflavones on menopausal hot flashes.”

I am going to skip over the science mumbo jumbo and get right to the meat of how they came to their ultimately conclusions:

• Findings were based on an analysis if 16 studies published between 1998 and 2012 enrolling over 1700 subjects.
• In terms of duration, the effect of soy isoflavones were studied for anywhere from 4 weeks to two years, with a median of 12 weeks.
• In these studies and vis a vis modeling, soy isoflavones were compared to both placebo and estradiol, the latter in terms of how long it takes to reach effectiveness. This last point is important.

And now, the result.

While the effect of isoflavones on hot flashes was superior to placebo, the researchers still observed a relatively strong placebo effect at play. Importantly, however, the placebo effect at play was even higher in trials examining estradiol and hot flashes. The reason? Apparently, women might have lower expectations when it comes to alternative therapies like soy. Yet, there was still another important finding that was teased out by this new modeling:

Soy isoflavones require at least 13.4 weeks to reach at least half of their  full level of activity in the body. In comparison, estradiol only needs about 4 weeks. So, when you do the math, at four weeks (which is the usual length of most clinical trials of this nature), estradiol has reached 80% of its peak activity level and soy isoflavones, only 47%. By 48 weeks, soy isoflavones catch up.

Additionally, as I’ve written time and again, there are different components of soy with differing levels of effectiveness. Genestein is the strongest and yet, only three studies specifically looked at soy agents that contained genestein only. So, there was no way for the researchers to break down the findings by components.

Overall, the key takeaway is that it takes longer for soy to reach maximum effectiveness than it does estrogen. So, if we are going to quantify value moving forward, it’s important to account for this significant distinction.

When it comes to soy, it may simply be that slow and steady wins the race.

Iso what? Iso who? Hot flashes, isoflavones and clinical trials

Posted by Liz on Mar 25, 2013 in hot flash | 0 comments

I’ve long been intrigued by the replacement of hormone replacement therapy with soy isoflavones. Yet, studies looking at their effectiveness for alleviating hot flashes and other vasomotor symptoms have been mixed. The reasons for this are multiple, and point to such factors as dose and actual composition of the supplements used, severity of hot flashes and how often women are taking isoflavones over the course of the day. Researchers have also discovered that only 20% to 30% of Westerners produce equol, (there’s even a dispute over this stat) a component of the potent isoflavone dadzein that has an affinity for estrogen and appears to be slowly cleared from the body;(note that both of these factors contribute to its beneficial effect against flashes.

Despite these challenges, what would happen is you simply upped the dose and/or frequency? Would it change the’ iso what’ or ‘who’ to an actual ‘iso yes!?’

That’s exactly what researchers sought to learn when they recruited 130 peri- and post-menopausal women with severe hot flashes (i.e. five or more  a day). Women who produced equol and those who did not were separated and then randomly asked to take placebo, low dose (33 to 66 mg/day) or high dose (110-200 mg/day) equol or placebo capsule (s) and take them once daily or two to three times daily. They also kept daily hot flash diaries, assessing each hot flash by its intensity, daytime or nighttime occurrence and how bothersome they were. They met with the research team face to face twice — 9 weeks in, and 3 weeks after the study completed.

The findings made it quite clear that dose and frequency are almost as important as whether or not a person is able to produce equol. In fact, when women took higher doses of isoflavones more frequently, they had 2.4 per day fewer hot flashes than women taking the lower doses just once a day. And, the flashes were significantly less severe. What’s more, most of these benefits were realized during the night, when, as most of us know, flashes and sweats are especially disruptive. Moreover, there was not much of a difference between women who are able to produce equol and those who are not; while these women did experience greater declines (as much as 10%) in both how intense their flashes were and how frequently they occurred, the difference was apparently not statistically significant.

So, let’s cut through the scientific clutter:

• Higher doses of isoflavones tend to have a greater effect than lower doses
• More frequent dosing (two to three times a day) appears to be more beneficial than once a day dosing.
• Greater benefits are likely to be seen in women who naturally produce equol, especially when it comes to hot flash intensity
• Both perimenopausal and menopausal women may potentially benefit from higher, more frequent dosing.

This type of research is just beginning and the findings need to be teased out in larger numbers of women. It’s also unclear if spreading the lower dose out throughout the day would make a difference. Still, what these findings do bring to light is an evolution of thinking and that’s what makes me most excited. Rather than determining that isoflavones are useless, researchers are finally starting to treat them as though they were pharmaceutical agents, using them in randomized clinical trials, varying doses, frequency and patient populations and truly, thinking outside the box.

Wednesday Bubble: Soy takes a hit (again). But what about S-equol?

Posted by Liz on Nov 14, 2012 in bone health, hot flash, nightsweats | 0 comments

Soy is back in the news again, with newly published data suggesting that isoflavones may not be particularly effective when it comes to menopausal symptoms. But I can’t stress enough on this blog that sources are as important as substance; in other words, not all sources are equal and neither are the women who use these alternatives.

So, let’s talk again about S-equol. But first, a bit of context is needed.

We know that soy isoflavones, primarily genistein, daidzein and glycitein have been suggested as an effective strategy for combating menopausal symptoms such as hot flashes or night sweats. The beneficial effects of soy are believed to be associated with the ability to soy isoflavones to attach themselves to estrogen receptors. Importantly, our brains contain certain estrogen receptors in hippocampus, which is responsible for consolidating both short and long-term memory and spatial navigation. Moreover, both genistein and daidzein have been shown to have a particular affinity for the very type of estrogen receptors that reside in the hippocampus, which is why researchers have been so interested in determining if ingesting soy can help combat the natural decline in memory and cognition. While findings have been mixed, some women appear to be better metabolizers of S-equol, a metabolite of a major soy isoflavone called daidzein. It has a particular affinity for estrogen receptors and possesses some estrogen-type activity of its own. S-equol is produced in the GI tract however the ability to actually manufacture it depends on the presence of certain microflora. Consequently, only 30% to 60% of individuals are actually able to produce S-equol on their own (although this figure is believed to be higher among Asians and vegetarians).

I’ve been writing about S-equol for a number of years and you can revisit those posts here.  Interest in S-equol is in part, related to its potential for augmenting the benefits of isoflavones; in fact, it is possible that women who are naturally producers of S-equol actually experience greater effects from soy products, and this is especially true when it comes to bone health. Hence, vasomotor symptoms — night sweats and hot flashes — aside, you may not want to give up on soy just yet.

So let’s talk bone health. It’s so critical as we age.Declining levels of estrogen are a primary cause of bone loss and resulting osteoporosis in women; indeed, one in five American women over the age of 50 have osteoporosis and about half will experience a fracture in the hip, wrist or spine as a result. What’s more, because osteoporosis is silent in its early stages, causing no symptoms, it’s critical that bone loss is halted or at least slowed either before or during the most critical phases strike. There is no time like the present to take preventive measures, even if you are in your 30s and 40s.

Where does S-equol fit in?

Last year, researchers demonstrated the daily S-equol supplements taken by women who are not naturally producers of S-equol, may improve bone metabolism and attenuate bone loss. And I reprinting this information because it’s too early for a soy verdict.

In this 1 year study of 356 healthy, postmenopausal Japanese women between the ages of 41 and 62, daily intake of 10 mg S-equol via supplement markedly reduced markers of bone resorption in blood and urine compared to women taking placebo pills or 2 mg or 6 mg of S-equol daily. In fact, in women taking the 10 mg dose for a year, declines in a  urinary marker of bone resorption (i.e. DPD) were roughly 21% greater compared to placebo. Measures of whole body bone mineral density also showed that S-equol supplementation protected against bone loss, although not to the extent as bone resorption. These results remained even after changes in height, weight, body mass index, lean and fat mass were accounted for. No participant experienced serious side effects from taking S-equol and hormone levels were not adversely affected.

Does this mean that you should rush out and purchase S-equol supplements?

One of the primary limitations of this study is that the process of bone recycling can take as long as 18 months and the time required to complete a cycle may actually increase with age. Thus, the duration of time that the women were studied might be too short to draw any definitive conclusions. Hence,  you may want to wait before you start taking S-equol. However, the evidence that’s building continues to put the weight on the benefits versus risks side. Only time will tell. Meanwhile – remember that the source of S-equol is important. If you are going to look for supplements, go for products that state that they are standardized on the label. Food sources, e.g. tofu, are always a good bet but again, not every woman will metabolize soy the same way. Still, here’s to yourhealth. Keep on doing all you can do to keep the faith and stay the course.

It ain’t over til the fat lady stops sweating!

Wednesday Bubble: your brain on soy

Posted by Liz on Jun 6, 2012 in memory/learning | 0 comments

Aging and estrogen. Gotta love it. It can signify the loss of reproduction, skin elasticity, vaginal lubrication, bones and even parts of our brain, at least hypothetically. Yet, can ingesting soy help improve attention, focus, problem solving and memory? A  newly published study in Neurology journal counters claims that it can, but adds further evidence that certain factors may influence benefits, such as reproductive age or if menopause comes on naturally or not.

A bit of context is needed. We know that soy isoflavones, primarily genistein, daidzein and glycitein have been suggested as an effective strategy for combating menopausal symptoms such as hot flashes or night sweats. The beneficial effects of soy are believed to be associated with the ability to soy isoflavones to attach themselves to estrogen receptors. Importantly, our brains contain certain estrogen receptors in hippocampus, which is responsible for consolidating both short and long-term memory and spatial navigation. Moreover, both genistein and daidzein have been shown to have a particular affinity for the very type of estrogen receptors that reside in the hippocampus, which is why researchers have been so interested in determining if ingesting soy can help combat the natural decline in memory and cognition. While findings have been mixed, some women appear to be better metabolizers of S-equol, which is related to daidzein, produced in the gut and targets estrogen receptors in beneficial ways that other soy isoflavones do not. If you click on the links posted above, you will find a wealth of information on soy and the research that has been done.

In this particular study, healthy, postmenopausal women received either 25 g daily of isoflavone-rich soy protein (more than 3/4 of which contained genistein and daidzein) or milk-protein daily; both were offered in the form of a powder or bar. Over the next two and half years, the participants visited the clinic at various intervals to participate in tests that measure their cognitive skills, including:

• Executive function (working memory, expression, general intelligence), and,
• Verbal learning, verbal memory and visual memory.

Although the women were not required to change anything about their diet, they were asked to refrain from taking soy supplements over the study course.

The findings? Researchers failed to observe any differences in cognitive function between women taking soy and women taking milk protein, even though scores did improve over the two+ year time period. Yet, they did note differences in improvements in visual memory scores, with women in the soy isoflavone group better able to recall faces both immediately and with a short delay compared to their milk protein peers. The group of younger, postmenopausal women in the study did not appear to have any advantages over the older women (note that age range was as broad as 49 to 94 years).

So, what to make of this? Is your brain on soy an improvement? Apparently, not really. What the researchers do say, however, is that surgical menopause may eventually cause a larger decline in cognitive function over time (these group of women actually showed a worsening in cognition regardless of whether or not they took soy). They also note that soybeans contain active constituents other than isoflavones (e.g. lignans) that may boost or detract from isoflavones effect on cognition.

Still, there is a wee bit of a silver lining. Although it’s true that if you are seeking a better functioning brain, you may wish to look elsewhere, a high soy diet can be consumed without fear of any adverse effects on memory skills that are associated with dementia in later life, and may possibly even improve them. The verdict is still out for women who are naturally high S-equol producers. In so far as hot flashes and night sweats? The evidence looks much better.

Estrogen’s a bitch, isn’t it? But who says that the bitch can’t be tamed or at least, kept at bay?!

Soy…revisited

Posted by Liz on Apr 9, 2012 in hot flash | 3 comments

It’s been a rough ride for soy, with studies often at odds regarding its effectiveness in ameliorating or preventing hot flashes. Some reviews have shown that soy isoflavones, in particular S-equol and genistein can alleviate hot flashes while others fail to finding anything conclusive. Still, the original observation that Japanese women appear to suffer less frequently from hot flashes and have a high consumption of soy isoflavones has led researchers to keep trying to tease out the benefits of soy.

I am glad that they have. In fact, in a study published online in Menopause  just a few weeks ago, researchers reported that an extensive review of 19 scientifically sound trials has shown that soy isoflavones are significantly more effective than placebo in reducing both the frequency and severity of hot flashes.

Here’s what you need to know:

• 19 trials were included for analysis and a variety soy isoflavone supplements in different doses ranging from 30 mg to 135 mg daily were studied. Some of these were natural formulations and others, chemically synthesized to match key ingredients believed to have a health effect.
• Hot flash severity and frequency were examined in women that were either premenopausal, perimenopausal or menopausal (i.e. postmenopausal) although definitions used to define this group differed between studies.
• The number of women in these studies totalled over 1,200.

The results showed that taking 30 to 80 mg soy isoflavones daily for 6 months to a year significantly reduced the frequency of hot flashes by roughly 17%. Moreover, the 10 trials analyzed for hot flash severity showed a significant reduction by as much as 30%. In both cases, these figures increased depending on how the researchers teased out and analyzed the data.

The researchers say that even though there is a common perception that results from soy trials have been mixed, there has been a “consistent and clear pattern in favor of isoflavones over placebo” when properly plotted on a graph. Moreover? The scientifically designed studies that were included in their analysis helped to insure that all populations, including women with breast cancer, were included. Additionally, they analyzed studies that were as short as 6 weeks in duration, namely to determine if women with cancer not receiving treatment would respond the same as healthy women. Additionally, there is some indication that the effectiveness of soy actually increases over time with continuous use.

What about the type of soy isoflavone? This review actually shows that genestein is more effective than daidzein for alleviating hot flashes.

The key take away is that for women who don’t want to use hormone replacement or are ineligible to do so, there is a scientifically proven effective alternative: soy. And while soy may disturb the GI tract in some women, it is actually quite safe, even among women with breast cancer.

So far, so good. The next step is to determine which factors matter most to gain benefit, e.g. dose, formulation, hot flash frequency and how long a woman needs to remain on treatment.