Posts Tagged "menopause"

Menopause? Apparently it’s in the genes…

Posted by Liz on Jan 30, 2012 in menopause | 0 comments

That is what scientists are reporting in Nature Genetics. They say that when they examined studies looking the genetic code for almost 39,000 women, the discovered that the timing of menopause may very well be linked to specific genes. What’s more, three of the 13 locations of these genes were directly associated with the immune system. The other important regions are associated with cellular repair, hormones and inflammation, all of which are linked with certain things that happen as we age, e.g. increased risk of developing certain illnesses, changes in appearance, and of course, ovarian function.

The researchers say that the study suggests that there is a genetic basis for when menopause begins and that it’s even possible that over time, they may be able to take some of these learnings to figure out why some women go through menopause prematurely or have fertility issues. Additionally, the potential role that immunity may play could open up other doors for general disease prevention and risk reduction, especially with regard to issues that especially affect women, such as breast cancer or heart disease.

Granted, there are other factors that may influence age at menopause, such as smoking or chemical exposure by our mothers while we were in the womb. Moreover, you may recall that researchers have identified a fairly simple blood test to predict age at menopause, although it is not yet being broadly used for this purpose.

Meanwhile? Knowing when you might start menopause can help with family planning, particularly if you get a late start, or place you on the road to healthy habits early when you are still able to prevent some of the things that seem inevitable, like thinning bones or chronic illness.

Stay tuned. Apparently it really is in our genes after all. At least in part.

Want to change the quality of your life? Bust a move

Posted by Liz on Jan 27, 2012 in aging, exercise, menopause, weight | 4 comments

The next time you place blame on hormones as the reason for things not going so well in your life, you may want to step back and move. I’m not talking about locale, but rather, moving your body. And researchers are saying that physical activity may actually be one of the most important things you can do to maintain or improve the quality of your life when hormones are wreaking havoc on your body, your mood and your outlook.

Granted, part of the reason for the improved life quality may have to do with amelioration of symptoms as a result of exercise. Indeed, you may recall a post from last month discussing the value of setting aside a precious hour for yourself for some sort of brisk activity. This new study adds fodder to the discussion, and suggests that even moderate increases in physical activity can improve overall life quality.

Importantly, this study, which involved over 1,100 women who were followed via questionnaire over 8 years, showed that a change in menopausal status acted as prompter to increase physical activity, and these women tended to experience greater improvements in their life quality than their peers who didn’t exercise or whose physical activity decreased over the time period. What’s more, as a side note, women in the study who never used hormone replacement therapy reported having a better quality of life than women who did use it, and even had 1.26 greater odds for improved life quality.

While the reasons for this are unclear, the researchers say that exercise may increase the production of endorphins, which in turn, work on symptoms, stabilize the body’s temperature regulation system and smooth out the flashes, sweats and other symptoms. However, most important is the point that the implications are far greater than feeling good: menopause may actually be a ‘window of opportunity’ to start improving your life by making healthier lifestyle choices.

But what do they mean by “exercise?” In this particular research, participants were asked to characterize their activity levels by:

1. The time spent on heavy physical activity on the days they exercise at least 10 minutes
2. The time spent on moderate physical activity on days they exercise for at least 10 minutes
3. Time spent on brisk walking on days they walk for at least 10 minutes

This information was then translated into metabolic equivalent (MET) hours per week, which measures basal metabolism and the amount of oxygen the body uses during exercise. You can find more information on MET as it relates to specific activities here.

The sum of all parts equals one thing: move. It’s important for symptoms, it’s critical for weight and it’s essential for health. And it appears to be the gold ring when it comes to life quality.

What are you waiting for?

Rage against the machine: menopause and irritability

Posted by Liz on Jan 16, 2012 in emotions, menopause | 1 comment

Last week I posted an amusing video about menopausal rage and parking lots. But is uncontrollable irritability really so funny?

An estimated 50% of perimenopausal women report irritability as a major symptom and it tends to worsen the deeper you get into the ‘pause. Depending on how severe hormonal fluctuations, it’s n0t unusual to have excessive and seemingly out of proportion responses to even the most mundane of activities (such as waiting on line at the bank). A road paved with irritability is truly a rocky one and one that will certainly be less well traveled by those people we surround ourselves with. But, without knowing exactly why irritability is so pervasive, it’s difficult to figure out how to address it properly: are mood symptoms during menopause independently linked to hormonal imbalances? Or, are they secondary responses to vasomotor and other symptoms?

Interestingly, researchers took a look at this very question in a small study of 163 peri and postmenopausal women, asking them to complete an 18 question scientific questionnaire designed to measure temporary psychological states. Irritability directed towards others was characterized ‘outward,’ while irritability directed towards oneself was characterized as “inward.” The findings? It appeared that levels of follicle stimulating hormone (FSH) and leutenizing hormone (LH) were significantly linked to outward irritability but there didn’t appear to be any similar correlation to inward irritability. Moreover? Women going through menopause who suffered from chronic illness, e.g. high blood pressure, heart disease, diabetes or thyroid disease had significantly higher scores on both inward and outward irritability measures.

So, do FSH and LH levels directly influence mood and more specifically irritability? Researchers say that there is a relationship but that there is no direct association; in other words, declining or fluctuating hormones don’t directly cause outward irritability. Clearly, it possible that fluctuating hormones as they relate to overall menopause may be responsible, but we still don’t really know. And aging, at least as it relates to being increasingly vulnerable to chronic illness, also appears to play a role.

And there hasn’t been enough research done specifically on this topic to explain why. Meanwhile, as Whoopie Goldberg once said “I don’t have pet peeves. I have whole kennels of irritation.”

Where are your whole kennels? And what are you doing to reel in the irritability when it wants to rear its ugly head?

All the rage…menopausal women

Posted by Liz on Jan 13, 2012 in aging, humour, menopause | 0 comments

I had hoped to go for the chocolate trifecta this week. But this video reminded me that I need to devote more time to laughing and less to the clinical side of this transition. While this is definitely a repost, it’s too good to pass up .

Happy Friday and Happy Weekend. Enjoy!

Sexual desire, age and a whole lotta debunking…

Posted by Liz on Jan 6, 2012 in aging, sexual desire, sexual health | 0 comments

I can’t tell you the number of times I’ve stumbled across studies or articles about sexual desire. She does, she doesn’t, he does, it doesn’t, take this pill, patch, supplement, eat this food, wear this article of clothing, blah blah blah. Guess what? A lot of it is in your head (or your environment). No really! At least if you are a woman. Granted, waning hormones, namely estrogen, will likely affect vaginal dryness, pliancy and libido, at least to a certain extent. But there is a whole body of literature that points to the importance of the value of, and satisfaction with, partner relationships.

I’ve been writing about sexual desire and sexual dysfunction since I started this blog four years ago. And I continue to be frustrated by the number of solutions and panaceas that overlook integral factors like emotions and intimacy. Consequently, I was truly happy to run across another piece of evidence demonstrating the importance of these factors. This time, researchers looked at a cohort of over 800 women who were as young as 40 and as old as 100 and asked them a number of questions about their emotional health, sexual activity and menopausal status. The results? 90% reported that they were in good health, and about half had had sexual activity within a month of being surveyed, with or without a partner. Notably, a large percentage of these women were using hormones.

However, while a third of women reported that they never or almost never felt sexual desire and a third reported having low sexual desire, most of the women who were sexually active indicated that emotional closeness with their partners was key and in fact, was associated with more frequent arousal, lubrication and orgasm. And, guess what? Although aging has often been thought to be a harbinger of low sexual satisfaction (or activity, for that matter), the percentage of women who reported being sexually satisfied actually increased with age, with about half of women older than 80 reporting that they were always or almost always satisfied! Moreover, these older women also had the same degree of orgasm satisfaction as their younger peers!

One of the study’s most important findings was the fact that sexual activity was not always the litmus for sexual satisfaction, and that emotional and physical closeness were almost equally if not more important. Indeed, lead researcher Dr. Susan Trompeter notes that women in the study “who were not sexually active may have achieved sexual satisfaction through touching, caressing or other intimacies developed over the course of a long relationship” adding that “emotional and physical closeness to the partner may be more important than experiencing orgasm.”

Clearly, this research highlights the need to focus on sexual satisfaction rather than sexual dysfunction or limitations to what is commonly perceived as sexual activity. By ignoring intimacy and partner relationships, we do a huge disservice to women. Moreover, it is certainly refreshing to know that it often gets better, not worse over time.