Posts Tagged "estrogen"

Wednesday Bubble: Testosterone and the metabolic syndrome

Posted by Liz on Nov 12, 2008 in heart disease | 4 comments

Today’s Bubble features a pretty interesting research finding: contrary to what experts have previously believed about the relationship between estrogen and the metabolic syndome evidence continues to accrue that testosterone may ultimately be identified as the culprit. I wrote about this in an earlier post and there are some interesting stats about risk, etc. (You may recall that metabolic syndrome describes the cluster of heart disease risk factors that include overweight, high blood pressure and blood sugar levels, high blood fats levels and low HDL-cholesterol.)

In the current study, published in the early online edition of the Menopause Journal, researchers evaluated 257 cases of metabolic syndrome found in a group of 1862 women enrolled in the Study of Women’s Health Across the Nation.

They found that the ratio of testosterone to estrogen during the menopausal transition, rather than changes in each individual hormone, was an important factor in determining which who would develop the metabolic syndrome. What’s more, faster increases in this ratio over time also increased risk.

What this brings to mind is the question of whether or not it is wise to use testosterone to improve sexual dysfunction during menopause? I’m going to be addressing this in a future post.

Hope springs eternal: black cohosh

Posted by Liz on Oct 18, 2008 in breast cancer, estrogen | 0 comments

There may be good news on the horizon for perimenopausal women with hormone receptor-positive breast cancer.  Researchers from the University of Missouri-Columbia are conducting an animal study to see how black cohosh and the tamoxifen interact.

Unfortunately, breast cancer patients who take tamoxifen to prevent their cancer from recurring, are unable to take hormones for menopausal symptoms that often occur as the drug starts working to shut down estrogen production. Consequently, one of the only options available to them are antidepressants, which are not always effective and depending on the agent, may cause side effects such as weight gain, fatigue or reduced sexual desire.

It’s a hopeful path that may help alleviate undesired side effects in women with breast cancer. If you’re interesting in reading more about black cohosh, you can click on the word in the tags category on the sidebar.

Wednesday Bubble: Rub-a-dub-dub

Posted by Liz on Sep 17, 2008 in appearance, estrogen | 2 comments

Is a youthful appearance only a rub-a-dub-dub away?

I ran across an interesting article in the UK’s Daily Telegraph on topical estrogen. Evidently, applying estrogen to the skin can stimulate collagen production and provide a more youthful appearance.

Seems like a great post for a Wednesday Bubble, right?

A closer read of the study on which the article was based suggests that it’s not quite that easy….or accurate.

Here’s what you need to know:

A University of Michigan research team evaluated the effects of applying various strengths of topical estrogen (estradiol) to the hip, forearm and face. Study participants comprised 40 postmenopausal women and 30 men (average age ~75 years). The cream, which varied in strength between 0.01% and 2.5%, was applied three times daily for two weeks. In addition to comparisons between the cream strengths, comparisons were also made to a placebo cream.

The results showed that topical estrogen applied to areas protected from the sun (i.e. the hip) increased production of procollagen I and III, and collagen I protein levels. For your information, pro-collagen type 1 is the precursor of collagen type 1, the most abundant form of collagen found in the body. Pro-collagen type III the precursor to the main component of the fibers that are found alongside the collagen.

However, no significant changes were observed in the photoaged skin of the forearm or the face, even though estrogen receptors were stimulated.

So, what’s the bottom line?

The study results suggest that while topical estrogen can stimulate collagen production in sun-protected areas, it does not affect the appearance of photo-aged skin, (i.e. skin that has been exposed to the sun or other elements).

In other words, topical estrogen is not yet a panacea for aging skin.

Burn Baby Burn Part 2

Posted by Liz on Sep 12, 2008 in heartburn | 1 comment

Regular acid, Heartburn? Have you taken hormones lately? Used OTC products like soy, wild yam or progesterone cream?

If you’re in that postmenopausal state of mind and continue to take prescription or OTC hormones for lingering symptoms, you may be placing yourself at risk for developing gastroesophageal reflux disease, better known as GERD.

A recent study in the Archives of Internal Medicine shows that use of estrogens,  SERMS, or OTC hormone preparations in the years following menopause (i.e. “postmenopause”)  is associated with a greater likelihood of GERD symptoms.

Researchers studied data from 51,637 postmenopausal women enrolled in the ongoing Nurses Health Study. 12,018 of women reported having GERD symptoms. What’s more, compared to women who had never used postmenopausal hormones, women who did had a 1.4 times greater odds of developing symptoms.

Here’s some other findings:

• Current users of estrogen had a 1.6 times greater odds of developing GERD symptoms
• Current SERM users had a 1.4 times greater odds of developing GERD symptoms
• Current OTC hormone estrogen users had 1.37 times greater odds of developing GERD symptoms.

The findings also suggested that risk increased with increasing estrogen dosage and increasing duration of use.

The researchers offered no suggestions for dealing with this problem.

I don’t know which is worse as symptoms are waning: continued flashing, sweating,  or a new one – burping?

Soy! Oh Boy!

Posted by Liz on Aug 27, 2008 in hot flash, nightsweats, women's health | 10 comments

It’s Wednesday, meaning that it’s time for me to debunk a popular myth about menopause or provide you with a bit of inspiration for hump day.

Tongues have been wagging a lot about soy isoflavones (plant-based compounds with estrogen-like properties)  with the most disturbing reports linking high doses to genetic damage and stimulation of estrogen receptors to promote breast cancer.

So, do you need to be worried if your current menopause diet includes lots of soy? (You can read more about the potential benefits of soy here.) Evidently, the answer is NO!

According to a newly published study in the Menopause Journal, unconjugated forms of soy isoflavones are safe and well tolerated at daily doses as high as 900 mg/day. (Unconjugated forms are more readily absorbed into the bloodstream.)

In this study, researchers administered soy isoflavones or placebo to 30 postmenopausal women for 84 days.  The goals of the study were to measure DNA damage, cell death and any changes that would indicate that estrogen was stimulated (which might lead to tumor growth). The researchers found no indication that high (900 mg) daily doses of soy caused DNA damage, increased cell death or affected estrogen. What’s more, any side effects (ocurring in only 1 woman) were mild or moderate in severity.

Granted, the study population is quite small and more data are needed to confirm these findings. Neverthless, the researchers do conclude that despite the considerable debate over the negative, estrogen-related effects of soy isoflavones, findings suggest only minimal effects.

If you are currently using soy isoflavones as a strategy to combat vasomotors symptoms like hot flashes and night sweats, eat with ease. It appears that you are not increasing your breast cancer risk. Nevertheless, as my grandmother used to say “everything in moderation.”

Happy News for Wednesday!

[Cross-posted at EmpowHer.com]