Search results for S-equol

Soy! Everything you wanted to know. Or should.

Posted by Liz on Sep 20, 2010 in hot flash, HRT | 6 comments

Confusion about soy abounds. Does it help hot flashes, improve bone health or prevent heart disease by lowering cholesterol? Or it is no more effective than placebo?  Does its effectiveness rely upon the ratio of certain isoflavones — the plant-based estrogen-like components, which in soy include  genistein (50-55% of total isoflavone content of soy), daidzein (40% to 45% of total isoflavone content) and glyceitein (5% to 10% of total isoflavone content) — or is the metabolite S-equol the only component that will yield estrogen-like benefits without negative health risks?

Are you perplexed? I sure am, which is why this particular post may be a bit to scientific for a few and too long for others. however, it’s important to understand some of the reasons why soy continues to intrigue, baffle and well, show differing results in terms of benefits for menopausal symptoms. So I encourage you to bear with me.

I’ve written previously that there are several key reasons why researchers have yet to make any any definitive conclusions about soy during menopause, such as poorly designed studies, small number of study participants, wide range of ages and years from menopause, and the fact that the pros and cons of an agent or strategy are not being studied for a long enough period of time. In other cases, there is an inconsistency in the soy preparation being studied and the ratio of isoflavones may differ; alternatively, researchers have not accounted for the presence of other isoflavones in the diet, which may influence results.

Does a new study that appears in the advanced online edition of Maturitas journal, comparing low-dose hormone therapy to soy powder in women with hot flashes, offer any anything more definitive or different than what’s gone before?

Briefly:

The 16-week study enrolled 60 women between the ages of 40 and 60, all of whom had had their last period at least 12 months, had the same frequency of hot flashes (more than 8 per 24 hours), had not used any hormonal treatment in the 6 months leading up to the study period, and were not currently using any drugs that lower blood fats, treat diabetes, taking other soy-based products or using herbal supplements.

Women participating in the study were randomly assigned:

1. low-dose hormone therapy (a Activelle ®tablet daily, better known as Activella® in the US) plus a placebo powder or
2. 2 portions daily of dietary soy supplementation powder (comprising 45 mg isoflavone per dose) plus a placebo tablet, or
3. 1 placebo tablet/2 portions placebo powder.

All women were first screened  for  current hormone levels, reproductive history, age at menopause, time since menopause, medication use and cigarette/alcohol consumption. During the study, they were asked to use a standardized scale to evaluate menopausal symptoms (hot flashes, heart discomfort, sleep, and muscle and joint problems) mood (depression, irritability, anxiety, physical/mental exhaustion) and sexual problems, bladder problems and vaginal dryness.

The results?

Both hormone therapy and soy supplementation were associated with significant improvements in hot flashes and joint/muscle pain (which declined by about 45.6% in the hormone group and 49.8% in the soy group) and in vaginal dryness (which decline d by 38.6% in the hormone group and 31.2% in the soy group) compared to women who took placebo. Improvements in mood scores were consistent between the three groups, indicating that other factors, such as caring and attention by medical practitioners throughout the study, may have played some role in wellbeing. Moreover, both treatments were considered safe with few side effects.

These results are quite promising, as they indicate that soy may indeed, offer an alternative to hormone therapy in menopausal women seeking relief. However, it’s important to consider the following:

• Like many of its predecessors, the study is a small one.
• The study length was short, lasting only 16 weeks, which some critics might say is too short a time period to elicit a satisfactory clinical response.
• The researchers did not analyze whether or not the women actually took the drugs or soy consistently, and relied on their self-reports.

On the other hand:

• The study followed strict Western scientific guidelines and the women and the researchers did not know who was taking what.
• Symptoms were measured using a common quality of life scale whose goal it is to diminish errors by healthcare practitioners when analyzing results of questionnaires. This particular scale, better known as the MRS, is widely used and allows researchers to evaluate symptoms and treatment over time.

There has been a lot of criticism geared towards alternative treatments, such as acupuncture, herbs and Chinese medicine, as being shams, especially because there is no evidence supporting their use for addressing troublesome menopausal symptoms. Others will claim that the placebo effect is at play, i.e. a situation in which symptoms are relieved by an otherwise ineffective treatment due to expectations or beliefs. However, the researchers of this particular study point to the placebo effect in studies comparing estrogen to placebo, demonstrating for example, a 75% reduction in hot flashes among hormone users compared to a 57% reduction in hot flashes among women taking placebo.

The most important conclusion to be drawn is that there is early evidence that soy supplementation may be as effective as low-dose hormonal therapy in relieving certain vasomotor symptoms and possibly, vaginal dryness. We need more studies like this one, enrolling larger numbers of women, in order to definitively demonstrate benefit. Dollar for dollar, the monthly difference between the two treatments may only be about $30.  Yet, this is one of the first studies I’ve seen that followed enough rules to quiet the rioters. And that alone, is worth the price of admission.

Stay tuned. The fat lady hasn’t sung her soy aria as of yet.

[Special thanks to Reuters Health Executive Editor Ivan Oransky, for your continued support of my mission to provide timely, evidence-based information on menopause and midlife to my readers.]

Random Roundup: news and tidbits picked just for you

Posted by Liz on Sep 6, 2010 in Uncategorized | 0 comments

[Credit: Special thanks to artist Darryl Willison of whimsicalwest.com. Please visit his site and support his work.]

I’ve decided to lose the monthly or quarterly Roundups and post them more sporadically. Moreover, since September marks the beginning of Fall, it seems like a great time to highlight some of the most interesting posts and news since July.  Be sure to check them out and feel free, always, to send me a note telling me what you’d like to see included in the next Roundup.

• A Different Kind of Hot Flash – Powerhouse blogger Erika Napolitano takes us down an often uncharted road: need not flashes.
• Is S-Equol the Next Big Thing? – This metabolite of soy isoflavones may actually be the key to reducing hot flashes, improving mood and promoting bone health!
• Are You Working Through the Transition? Or Is It Working You? – Women want their managers to understand how menopause can affect their work. The first step? Education.
• “Age-Appropriate” Dress for Women Over 50 – Welcome to the dark ages. Not for me, nnuh-uh.
• The Mommy Factor – It’s Personal – I may be childless. But I am not without children. You?

Menopausal symptoms? Treat them with Ease…

Posted by Liz on Aug 20, 2010 in herbal medicine | 3 comments

Or not.

I just wind of a new product called EaseFemin™, a supplement with a proprietery formulation that the manufacturers are calling IsoFactor™. These specific isoflavones and flavare derived from a unique Brazilian red propolis, which is a resin collected by honeybees. Evidently, propolis has been used in folk medicine since around 300 BC and clinical data show that it is non-toxic.

Theoretically, Ease-Femin™ taken once-daily, addresses irritability, hot flashes and night sweats. Moreover, an antioxidant has been added to fight cellular damage caused by free radicals circulating in the bloodstream.

Does this sound a bit too good to be true?

I would say, yes.

My first concern is that I did a search on propolis. And as an isoflavone compound, it’s not been studied extensively in menopause or any other condition. The second concern I have lies with isoflavones themselves. As I’ve written of late, it seems that only specific isoflavone compounds, namely S-Equol and daidzein, appear to have any sort of demonstrable effect on hormonal symptoms. So I am not entirely convinced about whether or not this is an exciting new avenue or the promise of spending money ($36.99 a month) for a product that won’t do much of anything.

This is another case of buyer beware. The research simply isn’t there to back the use of the product. At least not yet.

One a day…takes the menopause away

Posted by Liz on Jul 23, 2010 in menopause, women's health | 1 comment

Did you know that One-a-Day has a menopause formulation that theoretically reduces hot flashes, improves mood and addresses energy issues? Interestingly, if you compare it to One-a-Day for Women 50+, the ingredients and the amount of each vitamin and mineral are almost identical.

So, what makes the menopause formulation so much more effective for menopausal symptoms? Evidently, the addition of soy isoflavones, which, studies have shown, may help alleviate hot flashes or promote bone health. However, increasingly, researchers are focusing on S-equol, the compound in soy isoflavones that actually appears to make soy effective in addressing menopausal symptoms.  So, based on the evidence, it’s fairly unlikely that soy extract in a multivitamin is going to provide the relief you seek.

I’m not certain that their sponsored blog, Menopause Live, is going to either. Granted, sharing experiences via Menoplay (a video blog) is an empowering approach, but you have to wonder about the fact that the site reserves the right to edit the videos. Or the subtle implication that these women are not taking medications but rather, a vitamin everyday to cure what ails.

Look, I’m all for multivitamins and supplementation, physical activity, emotional support and sharing. But I don’t appreciate the veiled messaging or false claims that are not backed by research and data. I don’t like to be hyped, duped or taken advantage of. And I don’t support the idea of using women “just like you/me/them” to push product.

Do you really think that your symptoms are going to go away when you take a vitamin and push “play?”  Doubtful.

Don’t believe everything you read, see or hear.

The Roundup: November news and tidbits

Posted by Liz on Nov 30, 2009 in Uncategorized | 0 comments

[Credit: Special thanks to artist Darryl Willison of whimsicalwest.com. Please visit his site and support his work.]

Time for November highlights. A new feature, a few guest posts and lots of controversy in this month’s mix:

• Introducing….It’s raining men. It’s a new month and a new feature on Flashfree. I am looking for men to lend their perspectives. Here’s one guys’ take.
• Wednesday Bubble: Equol-ity. Can the plant-based S-equol alleviate hot flashes? The evidence continues to mount in its favor.
• Oh, baby – a new glam parent is born. Forty Weeks’ Julia Beck provides some important tips for Boomer grandparents on breastfeeding and support.
• Be still my heart. When it comes to heart disease, knowledge is power. Heart attacks are on the rise in midlife women. Wondering why?
• Wednesday Bubble: Bifocals, babies, hot steamy flashes of perspective. It is enough. Author Patti Digh graces the pages of Flashfree with her insight and wisdom: time to call in the dumpster.
• Hip fracture, early menopause and age. Researchers show that early menopause is not a risk factor for hip fracture. Here’s what you can do right now to keep your bones in good shape.
• Viva la sweats! Forget the sheets! Who knew that night sweats might actually save your life?
• Wednesday Bubble: One pill makes you…. Coming to bedrooms soon: the new Viagra-like compound for women.
• Dem bones were made for dancing. Who says you can’t have fun while boosting your bone health? ‘Dancing with the Stars,’ are you listening?
• New Flash! Just a spit away… Is comprehensive non-invasive testing on the horizon for women? Researchers say that your saliva may hold important clues to illnesses as you age.
• Wednesday Bubble: NutraFem promises much. Will it deliver? There’s a novel multi-botanical on the market and it’s looking promising for controlling hot flashes and night sweats.
• Battle of the middle-aged bulge: pick your poison. That abdominal donut may cause you to lose your mind, if you don’t have a heart attack first. Time to get moving!