Posts Tagged "HRT"

Wednesday Bubble: The incredible shrinking brain

Posted by Liz on Jan 14, 2009 in HRT | 2 comments

WHAT?!

New research from the Women’s Health Initiative Memory Study hormone trials demonstrates that HRT may shrink women’s brains. No wonder I can’t forget where I placed those files..

The data, which are reported in the January 13 edition of Neurology, show that women who took hormone replacement comprising estrogen with or without the addition of progesterone had an increased risk for dementia and overall decline of cognitive function.

Researchers measured brain volume and size of microscopic brain lesions in 1,403 women who took estrogen therapy for 18 months or combined estrogen/progesterone for three years or a placebo. The women who participated in the study were on average, about 77 years old.

The findings showed that women who took HRT had brains that were several centimeters smaller than women who took placebo.

The areas of the brain that were most affected by therapy? The hippocampus, which is involved in memory formation, and the frontal lobe which is involved in memory recall. However, no differences were seen in the sizes of brain lesions, which negates the possibility that HRT is leading to tiny strokes that cut off the brain’s blood supply and affecting memory.

When I looked into other reports of this study, I found quotes from the researchers that suggest that the greatest risk may be in women who already have memory problems. More importantly, the findings imply that the risks of postmenopausal hormone therapy may greatly outweigh the benefits.

These data do potentially provide some explanation as to why many women going through menopause experience increased forgetfulness. However, it is clear that the story is not yet complete, as many of us not taking hormones still seem to go through weekly, if not daily memory lapses.

Now…where did I put that….

More Sex: Another One Bites the Dust

Posted by Liz on Aug 5, 2008 in estrogen | 0 comments

[youtube=http://www.youtube.com/watch?v=hMenB9Ywh2Q]

Guess that I have sex on the brain these days.

Another theoretical benefit of HRT bites the dust.  Researchers at McGill University’s Laboratory for the Biopsychosocial Study of Sexuality have found that HRT is ineffective for alleviating painful sexual intercourse in a majority of postmenopausal women.

Approximately one in three postmenopausal women suffer from dyspareunia, or pain during intercourse. This has historically been attributed to declining estrogen levels and changes in the genital tract that lead to thinning skin.  HRT has long been used to treat this problem.

The McGill research team, led by Alina Kao, say that their findings suggest that numerous conditions that may be causing pain, such as infections or problems with pelvic floor muscles, are apparently being overlooked by most clinicians. Consequently, they suggest that treatment should be individualized.

The study is slated for publication in the journal Pain Research and Management. In the interim, you can learn more about the lab’s work here.

‘Like a roadmap that is ever changing’

Posted by Liz on Jun 25, 2008 in heart disease, HRT | 0 comments

The GPS certainly comes in handy when you’re in unfamiliar territory. But what happens if the territory changes suddenly, new streets replace old, and you’re unable to turn around?

Before menopause, women are protected from conditions such as heart disease, heart attack and stroke but lose this protection afterward.

Missouri University scientists believe that they’ve uncovered one of the reasons why: the body’s natural adaptation to a loss of estrogen. They say that animal study findings suggest that the vascular system depends on estrogen to maintain the status quo.  With a decline in estrogen production, the body loses its ability to regulate and maintain blood vessels the old way, and adapts by creating new “side streets” of vessels.  Women have are at increased risk for developing disease in these new vessels with symptoms that are subtler and harder to identify.

Study co-author Virginia Huxley, a professor at the Missouri University’s School of Medicine, likens blood vessels to highways that transport oxygen and other nutrients. She says that these roads are ‘ever changing’ after estrogen production halts. Importantly, the research team believes that adding estrogen to a system that has learned to adapt without it can upset the transition and lead to complications. This may be why HRT after menopause is counterintuitive and downright dangerous.

Cool!

Posted by Liz on Jun 11, 2008 in hot flash | 1 comment

Hey Hot flashers! Big news! I mean really big!

I just read an article extolling the virtues of a new device in development that claims to “beat the heat of a hot flash.” Denise Polacek, PhD, founder of Life Quality Technologies, has designed a wearable device the size of a heart monitor that will track temperature on the surface of your skin and then automatically turn on a thermoelectric cooler when you need it. This is welcome news for those of you who don’t want to do the HRT shuffle. I don’t know much else but I’m going to try to track this story a bit deeper and see if I can locate Denise for an interview.

In the meantime, no surprise but evidently a hot flash heats up the skin by 1.5 degrees F in just 30 seconds. Yikes! No wonder we’re all sweating!