Posts Tagged "Hormones"

Wednesday Bubble: The best medicine

Posted by Liz on Sep 16, 2009 in Inspiration | 3 comments

I’m especially happy to write this Wednesday Bubble because it’s inspiring and makes me want to jump for joy! Or better, yet, laugh a little.

Several years ago, researchers discovered that humor therapy and anticipation of laughing or being amused (also known as mirthful laughter) positively affects immunity. In fact, findings from a series of five separate studies among healthy men demonstrated that just anticipating watching a funny video could increase beta-endorphins (hormones that elevated mood) as much as 17% and human growth hormone (which contributes to more optimal immunity) by as much as 87%. Elevated hormones levels were maintained throughout the video and as long as 12 hours after. Conversely, hormone levels did not increase in men who who did not anticipate watching a humorous video and instead, browsed magazines.

Similar results were seen in another study among healthy adult women; this time mirthful laughter was associated with significant declines in stress hormones and improvements in natural killer cells, which contribute favourably to immune function.

More recently, researchers have been examining the effects of mirthful laughter on actual disease states. Findings of a year-long study presented this past April at the Experimental Biology Conference suggest that watching a funny, 30-minute video on a daily basis may impart a long lasting impact on health that includes:

• Lower stress hormones (epinephrine and norepinephrine) and related stress levels
• Lower levels of inflammation that can contribute to disease
• Significant improvements in HDL cholesterol
• Significant reductions in harmful C-reactive protein levels (a protein that increase the risk for heart disease, heart attack, stroke and death)

This particular study evaluated laughter in patients with diabetes, high blood pressure and high cholesterol who were also taking medication. Notably, similar positive outcomes were not seen in patients who did not have the benefit of watching the funny video.

What can we take away from this work and what does it have to do with menopause? Actually, I’d like to ask, what doesn’t it have to do with menopause and midlife?

During the transition, women are subject to hormonal stressors that affect mood, functioning, wellbeing as well as disease risk. If there are simpler, more natural ways to improve healthy states, for example, by daily laughter, shouldn’t we reach for them? I’d rather take a dose of funny over pharma any given day.

Here’s my gift to you: laugh today. And tomorrow. And the next day. And spread the joy. Nothing like a deep belly laugh to take some of life’s challenges away.

A little laughter may just go a lot further than previously believed.

Wednesday Bubble: Maca what?

Posted by Liz on Aug 19, 2009 in herbal medicine, Uncategorized | 0 comments

I love it when I run across an item that’s perfect for a Wednesday bubble; whether or not this one is “burstable” remains to be seen. There are accumulating data supporting the use of a Peruvian herb known as “Maca,” which reportedly balances hormones and consequently, alleviates certain perimenopausal symptoms.

In scientific communities, Maca is better known as Lepedium Meyenii (or more recently, Lepedium peruvianum Chacon ) and is a plant in the mustard family. In Norway, Maca is considered a medicinal substance and requires a prescription.

There have been a lot of claims about the aphrodisiac and energizing properties of Maca. For this reason alone, I am quite skeptical about whether or not the science behind the plant’s use in menopause is sound. Nevertheless, I did find several evidence-based, published studies examining Maca in peri- and post-menopausal women:

In two of the largest studies, a standardized, concentrated Lepedium peruvianum formulation (Maca-GO®) was compared to placebo tablet in 168 women who were in early post-menopause; treatment was provided for up to four months. Significant, beneficial changes were seen in balancing and normalizing hormones (estradiol, progesterone, follicular stimulating hormone and lutinizing hormone) and reducing menopausal symptoms, including hot flashes and night sweats.

In a much smaller, four-month study among perimenopausal women, all participants received Maca-GO® for two months and then a placebo tablet for two months. Two months of the active tablet resulted in anywhere from a 74% to 87% reduction in frequency of hot flashes and night sweats, as well as improvements in sleep interruption, nervousness, depression and heart palpitations. The authors, while acknowledging what is known as a placebo effect (i.e., “I want to believe it works so it does”) suggest that Maca-GO acts a hormonal toner. In this study, as in the one mentioned above, a balancing of hormonal levels was observed.

There is a new supplement called Femmenessence™ with two product lines – MacaPause for postmenopausal women and MacaLife for perimenopausal women. Like many other supplements, both claim to support the body’s ability to balance hormone and by default, address the many troublesome symptoms associated with menopause. Recommended dosage is twice-daily 500 mg capsules for the first four months with a one week break every two to three months. The manufacturer also recommends that women first speak to a healthcare practitioner before using Femmenessence.

As I’ve written time and again, the one-size fits all’ framework doesn’t work too well when it comes to hormones, let alone any other disease. Nevertheless, I am curious about Maca. What about you? Have you heard of or tried Maca? What were the results?

News Flash: Hot hot hot

Posted by Liz on Jun 19, 2009 in hot flash, HRT | 0 comments

[youtube=http://www.youtube.com/watch?v=nrhf_zgtmAg]

Think that hormone replacement therapy is going to get rid of those hot flashes forever? Think again. Indeed, researchers have discovered that the majority women who start hormone therapy because of hot flashes and then stop, may experience a recurrence of symptoms!

In this study, which appears in the Ahead of Print edition of Menopause, 1,733 women between the ages of 53 and 54 completed a validated questionnaire looking at menopause, hormone therapy and  vasomotor symptoms. Among the women who submitted completed surveys (~73%), 242 had previously used hormones and 69% indicated that they had vasomotor symptoms before starting therapy. Regardless of how long hormone therapy was used, symptoms returned in 87% women who stopped, even if they had completed menopause (although hot flashes were reportedly less frequent and bothersome).

The bottom line: Research has shown that disease risks, e.g. breast cancer, increase when hormone therapy is used more than five years. So clearly, remaining on hormones to address returning symptoms is not a wise option. Rather, safer and equally effective alternatives are needed to address return of symptoms as well as aid in disease prevention.

Gal pals – your second self

Posted by Liz on Jun 5, 2009 in Inspiration, women's health | 3 comments

Ever wonder why spending time with your girlfriends boosts your mood? Researchers from the University of Michigan report that emotional closeness increases progesterone levels and leads to greater bonding between people. Is it possible that social bonding and sharing may help to counteract waning progesterone levels during the the menopause transition as well?

To measure the influence of social bonding on progesterone levels, 160 female college students were randomly assigned to partners and asked to perform tasks:

• Ask one another specific questions geared towards allowing them to get to know one another better and promote emotional closeness (e.g. “Given the choice of anyone in the world, whom would you want as a dinner guest?”)
• Proofread an “emotionally neutral” article together

Before and after each session, the researchers took saliva samples to measure progesterone and stress hormone (cortisol) levels. All sessions were held at the same time (between noon and 7 pm) to insure that factors such as fluctuating daily hormone levels would not interfere with the results. One week later, all study participants returned, played a computerized card game and had their hormone levels measured again.

The bonding between the women caused progesterone but not cortisol levels to increase. Moreover, an increase in progesterone levels tended to influence the likelihood and willingness to make sacrifices on behalf of a study partner (i.e. risk one’s life) when measured again one week later.

The researchers say that the study findings help to explain why social contact has well-documented health benefits. It also appears that progesterone, like other hormones involved in bonding and helping behavior, enables individuals to suppress self-interest in order to take care of family or friends.

I’ve written previously on the importance of social support and bonding, not only during the transition but during our entire lives. Clearly, helping and supporting our sisters during good and bad times helps overall wellbeing and lends our souls a bit of a boost on our journeys.

Give a gal pal a call, send a hug, provide a smile, caress her soul, take care of her “self” as much as yours’.

A friend, as it were, a second self. Cicero.

A B C…

Posted by Liz on May 26, 2009 in estrogen, memory/learning | 3 comments

Study results reported in the May 26 issue of  Neurology suggests that the menopause transition negatively affects women’s ability to learn.

Researchers evaluated 2,362 women between the ages of 42 and 52 for verbal memory, working memory and the speed at which they proceesed information. All study participants were tested through the four stages of the menopause transition:

1. premenopause (no change in menstrual periods)
2. early perimenopause (menstrual irregularity, no gaps in period for 3 months)
3. late perimenopause (having no period for 3 to 11 months)
4. postmenopause (no period for 12 months)

The results showed improvements in processing speed during pre- and early perimenopause and postmenopause that were 28% larger compared to those in late perimenopause. Improvements in  verbal memory were 29% larger in permenopause than in  early or late perimenopause, and and become 36% larger compared with postmenopause.

The researchers said that it appears that during the late and early menopause, women do not learn as well as they do during other stages. What’s more, these findings support prior self-reports that suggest that as many as 60% of women have memory problems during the menopause transition. (Notably, there have been some studies that suggest that this is a fallacy.) The study authors add that this lapse in learning ability tends to be temporary and returns during the postmenopause stage. They also point to findings that show that taking estrogen or progesterone before menopause may help to improve verbal memory or processing speed but this effect can be reversed if hormones are taken after the final menstrual period.

This is an interesting study and the findings seem to jive with personal experience, especially with regards to what sometimes appears like a diminishing abilty to process information.  It makes me wonder if taking classes as I go through menopause is a good idea or not! And it equally makes me question the endless havoc that hormones appear to take on our bodies and our minds.

What about you? I’d love to hear your experiences and where you are in the transition, that is, if you can remember to comment after reading this (!)