Posts Tagged "breast cancer"

Imagine there’re no….flashes

Posted by on Jul 18, 2010 in hot flash, mind-body therapy | 0 comments

It’s easy if you try?

Wow! What a concept, eh? Well, it might not be so far-fetched, at least according to researchers at Baylor University. Writing in the International Journal of Clinical and Experimental Hypnosis, they say that cool imagery might actually reduce the incidence of hot flashes.

Two years ago, I wrote about Baylor research that showed that hypnosis could reduce hot flashes up to 68% in breast cancer survivors. This time, the investigators asked women who had survived breast cancer to participate in five weekly  hypnosis sessions and also, to describe mental images they would use for reducing hot flashes before undergoing hypnosis. Women who participated in the study were also taught self-hypnosis techniques and were encouraged to practice daily using their preferred imagery.

The results?

Overwhelmingly and not surprisingly, the women preferred cool over warm images. In fact, more than a quarter visualized something cool water-related such as a waterfall or rain or shower. Other images included cool air or wind, cool mountains, leaves and forests and snow.

The researchers say that while more study is needed, the findings might actually help to equate certain parts of the brain that are activated through imagery to those activated by perceived events.  Conversely, it is possible that in the case of hot flashes, “think” cool equals “feel” cool although I remain less convinced of this personally.

Regardless, I’d love to see more on this as Baylor researchers continue to delve into the brain mechanisms that control hot flashes with their minds. Imagine that…

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Flashfree food for thought: lignans and breast cancer risk

Posted by on Jun 7, 2010 in breast cancer | 1 comment

I’ve written previ0usly about the potential benefits of flaxseed in boosting bone health and alleviating hot flashes.  Now, researchers are suggesting that flaxseed and other foods that contain high levels of lignans –  a type of phytoestrogen with both weak estrogen and antioxidant activities – may also help lower the risk of breast cancer in postmenopausal women.

In a large analysis of 21 studies examining possible links between lignan intake and breast cancer risk, the researchers found that including large amounts of lignan in the diet reduced the risk of developing breast cancer by as much as 14% in postmenopausal women. What’s more, risk was reduced by as much as 16% in studies that specifically examined levels of compounds called “enterolignans,” which are created with dietary lignan enters the stomach and interacts with bacteria residing in the intestines. The researchers say that lignan may offer moderate protection against breast cancer because it blocks estrogen activity that promotes tumour growth, perhaps mostly when natural estrogen is low (i.e. during menopause). However, the study did not provide details as to what constitutes “large” amounts of the compounds.

Flaxseed is one of the richest dietary sources of lignan, although it is also found in other foods including sesame seeds, sunflower seeds, whole grain breads, muesli, kale, broccoli, white cabbage and brussel sprouts, apricots and strawberries. You can find a full list of the lignan content in foods here.

Should you start eating more lignan? The good news is that the foods that are richest sources of the phytoestrogen are also quite healthy.  And, wth the potentially added benefits of preventing osteoporosis and lessening hot flashes, it seems that boosting lignan intake is a win-win all around!

Want to read more? Reuters Health has an excellent write up with additional information on the study.

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Wednesday Bubble: herbs and breast cancer

Posted by on Apr 21, 2010 in breast cancer, herbal medicine | 1 comment

Can herbal medicines used for hot flashes, namely black cohosh and phytoestrogens, be safely used in women who’ve had breast cancer?

If you’ve had breast cancer, you’ve probably been told to stay away from herbal medications, right? Yet, women who’ve had breast cancer know that hot flashes are a common side effect of many cancer therapies. Research also suggests that the older a woman is at the time she receives chemotherapy, the more likely she is to develop menopause as soon as treatment stops. Moreover, roughly 80% of women taking Tamoxifen have hot flashes and about a third of those women rate them as severe. Hormones are not even an option due to the increased breast cancer risk.

The good news is that an extensive analysis of scientific studies shows that black cohosh might be safe for women who have had breast cancer. Although the researchers note that the evidence for the effectiveness of black cohosh for alleviating hot flashes is mixed, they cite research from the National Institutes of Health and other reviews that suggest that use of black cohosh in former breast cancer patients requires only standard screening. They also report that there is “little reason for excluding patients with estrogen-responsive tumors from using black cohosh.” In fact, recent laboratory studies, although not yet carried out in humans, suggest that black cohosh may actually protect the breast from developing tumors.

The case for or against the use of phytoestrogens (e.g. soy, red clover, chaste tree berry and flaxseed) in women with breast cancer is not quite as clear as it appears to be for black cohosh. In one of the largest reviews examining soy or red clover for menopausal symptoms, the outcomes were equivalent to placebo. Other studies have shown that they might be beneficial for women with mild to moderate symptoms who start menopause early.  Moreover, while red clover in particular does not appear to affect certain breast cancer risk markers, reports about phytoestrogens in general, especially in estrogen positive cancers is conflicting. Still, the American Cancer Society does not advise against eating soy-rich foods by women who’ve had breast cancer. Some studies have also showed improved prognosis.

If you are wondering if there are any drawbacks, one of the largest challenges is that there are not that many studies looking at herbal medications in women with breast cancer and the ones that do exist are mostly short in duration. The researchers point out that because herbs can take awhile to work, a three month study might be too short to form a conclusion.

Clearly, more study is needed. In the interim, it appears both black cohosh and soy might be safe to try if you’ve had breast cancer. As always, the most important consideration is to speak to a certified practitioner who is well versed in herbal medicine and make sure that she or he works with your oncologist.

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Wednesday Bubble: No pain, no…killing two birds with one stone?

Posted by on Mar 24, 2010 in breast cancer, menopause, ovarian cancer | 0 comments

Got pain? It is possible that if you regularly use aspirin, acetaminophen or NSAIDS (e.g. ibuprofen) during menopause, you may be reducing your risk for breast or ovarian cancer as well. Sort of a two birds with one stone approach. I like it!

This latest bit of great news comes from analyses of blood samples and questionnaires collected from  740 women who participated in a breast cancer trial as part of the Nurses Health Study, an ongoing investigation of factors that influence women’s health. At the time that information was collected, the women had no cancer, were in menopause and had not used hormones.Study findings, which are published in Cancer, Epidemiology, Biomarkers and Prevention showed that on average, mean levels of naturally  estrogen (i.e. estradiol), were more than 10% lower among women who reported regular use of aspirin or NSAIDS, and 15% lower among women reporting use of any sort of analgesic agent.

Although this specific study did not look at the link between hormones levels and cancer, previous studies have shown use of NSAIDs may lower breast cancer risk by as much as 12% to 25%; the evidence for ovarian cancer isn’t quite that strong.

Mind you, researchers say that these results don’t actually confirm if aspirin-like drugs cause estrogen levels to drop but there is an association. More research is needed to see if there is a firm link between declines in hormones after analgesic use and lower risk or breast or ovarian cancer. If it is true, there is a possibility that aspirin-like drugs could be used more regularly in this fashion.

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HRT – the cat’s outta da bag

Posted by on Dec 14, 2009 in HRT | 0 comments

Does Wyeth’s hormone replacement therapy agent Prempro cause breast cancer? Yes, according to a jury, who recently awarded Connie Barton $75 million in punitive damages.

According to a statement quoted in a New York Times expose, a spokesperson for the pharma giant Pfizer (which recently merged with Wyeth) emphatically claims that Preempro is “a safe, federally approved drug that did not cause [the woman’s] breast cancer.”And yet, Preempro is the very same drug caused the abrupt halt of the Women’s Health Initiative trial when it was found to double the risk for breast cancer as well as increase the risk for heart attack, stroke and blood clots. Moreover, later analysis of the Women’s Health Initiative data showed that hormones also increased the risk for dementia in a subset of women. Still, the company plans to fight every Preempro award, maintaining that it has acted responsibly and has posted every warning in line with FDA guidelines.

So what do you do when a drug has known dangers, a warped risk-benefit ratio and is still widely marketed? As I’ve written time and again on this blog, many in the medical profession continue to believe in HRT and  prescribe it regularly,  not for “good health” or to slow the aging process but to control the more troublesome symptoms of menopause (e.g. hot flashes, night sweats and vaginal dryness). And thousands of women continue to toe the party line, believing that that hormone replacement is essential to easing the aging journey (as the article’s author so aptly points out, the term “replacement” implies that it is something that is needed).

Interestingly the article maps out strategies that have been used to influence physicians, professional societies and women so as to deflect attention away from cancer concerns towards the positive, risk-preventive properties of hormone therapy. And while this piece makes me want to jump on my soapbox, I won’t attempt to dissect it further because it’s one of the most thorough and well-researched articles I’ve read in some time.  The only thing I will leave you with is that Wyeth’s actions are a true reflection of everything that’s wrong with the modern view of menopause, from menopause as a disease to waning estrogen as a symbol of all that is unattractive about an aging woman.

Rather than “rebalancing” our bodies through modern medicine, shouldn’t we be focusing on what we can do to balance the transition as we move through our lives by focusing on our relationships, our activity levels, our psyches, our connections and our diets? You can’t fix something when it’s not broken. And the only thing that appears to be broken here is the hype.

Yes, the HRT cat’s outta da bag. What do you think?

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