Search results for depression

Looking through the window: depression and menopause

Posted by Liz on Dec 27, 2010 in depression | 2 comments

There’s a new term that’s being kicked around in medical circles: ‘windows of vulnerability.’

It appears that a growing body of evidence supports the fact that during times of hormonal flux or reproductive cycle “events,” women become increasingly vulnerable to mood swings, anxiety and depression. And while this is certainly not news for many women, it still requires some attention because among the many windows that women may go through, the menopausal transition is evidently one of the most complex. The reason? This is a time when hormones interact with aging, sexuality, life stressors, self-esteem and general health issues.

The subject of depression and menopause is not new to this blog, nor are statistics suggesting that as many as 20% to 40% of women are believed to suffer major depression or at the very least, depressive symptoms during the peri/postmenopausal years. Moreover, women may have as much as a two- to four-times increased risk of developing depression as they transition from pre- to perimenopausal status. Among the multiple factors at play, estrogen is one of the most important; estrogen has been shown to promote the amount of the mood neurotransmitter serotonin available to the body, thereby providing an important antidepressant effect. However, a recent review suggests that the role that hormones like estrogen play in depression is directly related to their wide fluctuations rather than the fact that they are becoming deficient.

So, why is this important? For one, it highlights that hormone replacement is not the only answer for depression during menopause but rather, that it’s critical to pay attention to timing, i.e. when preventive strategies, including exercise, behavioral therapy and antidepressants might yield the greatest long-term benefits. Yet, it also suggests that estrogen-based therapies may indeed have a role in depression during menopause. And, since estrogen alone therapy has been shown to up the risk for ovarian cancer except for in women who’ve had hysterectomies, it also helps supports the need to explore the role plant-based estrogens in treating menopausal depression; fortunately, S-equol has already shown promise in this regard.

Feeling the window of vulnerability? There’s no time like the present to insure that you aren’t simply looking through the window but actually seeing that there’s hope and help on the other side. There are a lot of resources and strategies available to address depression during this time of life. While depression may be a “menopause-associated risk,” like others, it can be successfully ameliorated.

Thank you to Dr. Claudio Soares from McMaster University for an excellent review of depression in menopause and the inspiring, succinct “windows of vulnerability” terminology.

Omega-3s and depression

Posted by Liz on Nov 12, 2010 in depression | 4 comments

According to recent estimates, more than 20% of women undergoing menopause have major depressive disorder. In fact, mood disorders and depression affect a disproportionate amount of women in the peri- and postmenopausal stages compared to women in pre-menopause. Moreover, these mood disorders tend to occur in conjunction with hot flashes.

While researchers have yet to discover the cause of the depression/mood surge during menopause, they continue to explore therapeutic strategies that might help to take the edge off. And surprisingly, numerous studies actually point to the value of omega-3 fatty acids — eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) — for alleviating depression. Besides wellbeing, one of the reasons this is so important is that research has linked depression with other serious conditions including heart disease and stroke. The one thing that all these conditions have in common is that they are believed to be caused, at least in part, by an inflammatory response by the body. One particular action of omega-3 fatty acids is that they have been shown to lower inflammation, which makes them potentially useful in treating disease.

So, can omega-3s help stave off depression in menopausal women? In a very small study published in the online edition of Menopause, peri- or postmenopausal taking daily omega-3 fatty acids  (Lovaza, 2 g daily) for 8 weeks had significant declines in depression scores, number of daily hot flashes and hot flash interference scores.  During the course of the study, 70% of women responded, and those whose depressive symptoms declined also experienced declines in hot flashes, indicating both a connection between the two and a possible role for omega-3s in menopause.

However, this study was very small, enrolling only 20 women and more evidence is needed with larger numbers of women before omega-3s can be recommended as a treatment for mood and hot flashes during menopause. Moreover, it’s essential to note that a thorough analysis of scientifically sound studies has recently pointed to the EPA component as driving as much as a 56% reduction in depressive symptoms, that is, if the supplements used contain more than 50% of standardized EPA or pure EPA. Therefore, when it comes to fish oils, the ratio of EPA to DHA may play an important role.

I’m excited because this study brings us another step closer towards demonstrating that menopausal symptoms can indeed, be effectively alleviated without hormonal therapy.

Wednesday Bubble: heart disease, depression and menopause

Posted by Liz on Dec 30, 2009 in depression, heart disease | 1 comment

Today’s Bubble is not exactly bursting with good news. On the other hand, it more a matter of erring on the side of caution.

Depression in menopause and midlife is a common occurrence. Although researchers are not quite sure of the exact reasons for its surge during the transition,  (e.g. declining hormone, life stress, prior history), many women tend to suffer the blues during this time. In addition to physical activity or herbs, many practitioners recommend that women incorporate a low-dose antidepressant into their daily strategy. Yet, while this might help to maintain mood balance, researchers are starting to question whether or not using antidepressants may increase the risk for dying from heart disease during menopause. Yikes! So, we are given drugs to help boost our moods during menopause but they may end up killing us in the long run? Somehow the old adage, ‘what doesn’t kill you makes you stronger’ doesn’t make me feel better this time.

In a study that appears in the Archives of Internal Medicine, researchers examined information collected from over 136,000 women who had participated in the Women’s Health Initiative Study who either were or were not taking antidepressants over a period of about 6 years. The findings? Women who used SSRI antidepressants had a 45% increased risk of stroke, and a 32% increased risk of death.  This risk remained even after researchers took other heart disease risk factors into account, such as diabetes, high cholesterol and smoking.

Here’s the rub: depression is a known risk factor for heart disease and death from heart disease, and has also been linked to an increased risk for stroke. So, researchers are not certain if it’s the chicken (depression) or the egg (antidepressants) that is accounting for these study results.

So, what can you do? Should you throw away the pills?

Not so fast. Speak to your doctor. Get tested for known heart disease risk factors, such as overweight, high blood pressure, high cholesterol, family history, diabetes and of course, smoking. Incorporate heart healthy changes into your life, such as physical activity, a better diet, yoga, meditation and laughter. And then figure out if the benefits of antidepressants are worth the risks. These data are early and inconclusive. Just something to be mindful of if you are in menopause.

Wednesday Bubble: “Severe depression? Apathy? Psychomotor retardation?” How about a bennie?

Posted by Liz on May 11, 2009 in emotions | 0 comments

Every now and then, a post deserves a second viewing. This week, I’m bursting the bubble on more vintage advertising. Nothing like an upper for the mid-week blues, right?

“In the severe depressions of the menopause, marked by apathy and psychomotor retardation…”just use a bennie. You’ll be speeding through your day in no time! (And will probably lose that extra weight too!)

Really! What WERE they thinking?!

GUYSIDE: Keep a weather eye out for dubious claims.

Posted by Bob LeDrew on Dec 24, 2014 in aging, exercise, Guyside, health, general | 0 comments

Take a hint from Pepe, and be skeptical of medical claims — the more grandiose the more skeptical!

I was watching my local newscast recently and heard about an innovative new treatment for “winter blues”, or Seasonal Affective Disorder. As someone who strongly dislikes 4 pm sunsets, I was interested enough to keep watching.

The treatment is a device called the Alpha LED Light Spa. This device, which resembles a tanning bed, offers a variety of programs that combine light, heat, and oxygen to treat a variety of symptoms. The owner of this particular device told the reporter that it was an effective treatment for more than 1000 disorders — and that REALLY got me interested. Here’s the list:

“Energizing Whole Body, Mind and Spirit, Cold/Flu, Sleep/Insomnia Improvements, Depression, Seasonal Affective Disorder, Mind Clarity, Meditation, Pain Relief, Lymphatic drainage, Wound Healing , Immune Boost, Stress Relief, Detoxification, Weight Loss, Cellulite Treatments, Skin Care – Acne Treatments, Skin Care – Anti-Aging, Addictions, Balances hormones, Migraine relief, Soothes nervous system, Lowers cholesterol, Infertility, Psoriasis, Anxiety, Inflammation, & more.”

Unfortunately, there’s no links to evidence on the site. And I haven’t been able to discover any in my time looking around. There is little doubt that SAD, disruptions in sleep due to circadian rhythms, and depression can be treated effectively by light therapy. But on the face of things, it seems unlikely that this device would be able to successfully treat more than 1000 problems.

Claims like this need to be taken skeptically, not least because at the Ottawa spa offering these treatments, it’s $75 per session.

And there’s no shortage of claims that need to be given the side-eye. Also this week, an article in the British Medical Journal looked at medical recommendations made on the Dr. Oz show and The Doctors. In the case of Dr. Oz, fewer than half of the medical recommendations provided had any sort of supporting evidence backing them up; 1 in 6 were actually contradicted by medical evidence.

It’s easy to make a medical claim, and ones that fit into what we want to hear (eat this and your belly will magically shrink!) are much more readily consumed by us humans than ones that are a little more work (eat less, move more, and stop with the Big Gulps).

You owe it to yourself to ensure the actions you take to preserve and improve your health are ones that have a basis in fact.

For those who’ve just finished celebrating Chanukah, and for those who are anticipating a visit from Santa, Merry Christmas and Happy Holidays!

(Photo is CC-licenced from Flickr user Yiie)