Search results for flavonoids

Cocoa loco? The lowdown on chocolate and heart disease

Posted by Liz on Jun 17, 2011 in heart disease | 0 comments

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If you are a chocoholic, I bet you’ve noticed the headlines linking chocolate to a reduced risk of heart disease. In fact, data from the Kuna Indians (a tribe indigenous to Panama) have shown that cocoa and in particular dark chocolate are associated with declines in blood pressure. More recently, a large government study showed an even greater benefit in terms of a significant reduction in coronary heart disease prevalence. And in women, who have an increased risk for heart disease as they age (not only due to the increase in abdominal fat or changes in their blood fat levels but also to loss of ovarian function), chocolate has ben shown to slightly lower the risk of dying from heart disease.

Sounds promising and quite frankly, awesome, right?

Well…before you run out to the grocery or chocolate shop, you may want to read further…

Researchers have long been interested in flavonoids and in particular (at least in so far as menopause goes) in isoflavones. (See soy posts for more on isoflavones). The specific compound or molecule of interest in cocoa (the non-fat component cocoa bean extract or liquor) are flavanols, which are also found in lower concentration in apricots, peaches, apples, green and black tea, red wine and cider). Note that the quantity of flavanols in chocolate depends on manufacturing, including fermentation and roasting, and how much treatment is given to reducing bitterness and improving consistency. What this means is that dark chocolate has the highest concentration of flavanols and milk, the lowest.

What have researchers learned so far?

• Flavanols found in cocoa and cocoa powder may be powerful antioxidants and as such, help to mitigate certain factors that contribute to atherosclerosis, such as the formation of plaques in the arteries that lead to stroke and other coronary events. Thus, as antioxidants, they may actually neutralize toxic oxygen species circulating in the bloodstream.
• Experimental data suggest that ingestion of flavanols may help to regulate proteins and other compounds that encourage an inflammatory response to leads to heart disease.
• Flavanols may also help to stabilize the lining and muscular tone of the arteries and prevent them from narrowing.
• Additionally, flavanols may moderately protect against high blood pressures, although studies have been mixed.
• Finally, flavanols may help to maintain blood sugar levels and improve the ratio of good to bad fats in the blood.

Wow, this sounds fantastic! And all it takes is a daily diet of dark chocolate?

Here’s the great news. Researchers are devoting increasing amounts of time toward learning how certain foods affect (and benefit) health. However, in so far as chocolate goes? In a thorough review published online in Maturitas, they write that of the studies that have been conducted, it’s truly difficult to determine whether or not there is a causal relationship, i.e. eating A causes B, or eating chocolate prevents heart disease. In the case of chocolate in particular, factors like manufacturing can influence study findings. Moreover, researchers still aren’t sure if they should be focusing on flavanols or some other component of cocoa. It is also possible that only people who already have some sort of problem or condition will benefit  from eating more chocolate.

The bottom line? Dark chocolate in moderation, won’t hurt you and may actually help you. However, you may want to temper expectations. At least a wee bit. Dare to dream though…perhaps cocoa will ultimately defy explanation!

Wednesday Bubble: all juiced up and ready to go

Posted by Liz on Dec 1, 2010 in heart disease, physical fitness, weight | 0 comments

Did you catch last week’s news about pomegranate juice and kidney disease? It seems that pomegranate juice just might be the next best thing… or not. The same holds true for orange juice, weight loss and heart disease. So before you get too excited about the wonders of the orange, let’s take a look at what research is telling us.

Middle-age is associated with a slow down of metabolism, distribution of weight and of course, an increase in risk for certain diseases, in particular heart disease. For women specifically, hormonal changes – namely a steeply progressive increase in testosterone, can contribute to a risk of developing metabolic syndrome (i.e. the cluster of risk factors — abdominal fat, high blood pressure and cholesterol levels and insulin resistance –that increases the likelihood of developing heart disease and diabetes). In fact, data from the Study of Women’s Health Across the Nation has shown that women have a a 1.45 times increased risk of developing the metabolic syndrome in perimenopause and a 1.25 increased risk after menopause. So, the cards are automatically stacked against us. Let’s add overweight and obesity, poor eating habits and sedentary behavior to the mix and we have a veritable “heart condition in the making” cocktail.

Wondering where this is going?

Across the board, the key ways to improve one’s risk of developing disease include a balanced diet rich in fruits, vegetables, whole grains and good fats and regular physical activity. The formula isn’t a magic one and but it’s been shown time and again to improve the odds. However, we are a society of instant gratification so it’s easy to fall into the trap of a quick fix, whether that entails botox, diet pills, diet plans, sweating or the like without paying much attention. Hence, when I saw a study setting the stage for the latest and greatest answer to our problems, i.e. orange juice, I had to take a closer look.

Like pomegranate juice, orange juice is rich in flavonoids, naturally-occurring plant and vegetable compounds that have both antioxidant and anti-inflammatory properties. Orange juice is also an important source of vitamin C, folate and potassium, which have been shown to help protect cells from bad, LDL cholesterol, reduce the risk of atherosclerosis and possibly help lower blood pressure. But, can drinking orange juice help prevent heart disease in middle-aged women who are already at risk?

When researchers compared 26 premenopausal women between the ages of 30 and 48 who were considered overweight or obese, and asked them to engage in a 1-hour aerobic exercise (running) 3 times a week and either drink 2 glasses (16 oz) of orange juice daily or not, they observed the following:

• Regular aerobic exercise led to an average loss of 11% to 15% of fat and 1.2% to 2.5% of BMI depending on the group that women were assigned to.
• Women who drank orange juice along with their thrice-weekly exercise had as much as a 15% decline in LDL-cholesterol and an 18% increase in HDL (good) cholesterol.
• Daily orange juice intake also led to less muscle fatigue and better overall responses to aerobic training.
• Although drinking orange juice added to daily caloric intake, it actually led to a decreased consumption of other foods.

Should you start drinking orange juice to lose weight and save your heart? Not so fast. This study simply shows an potential associated benefit and does not prove that drinking orange juice causes a reduced risk in heart disease,; mind you, these women were only studied for three months. Moreover, the study was small and a much larger group is needed to demonstrate proof of a benefit. Additionally, the results did not show which components in orange juice are specifically linked to a potential risk reduction, or if there are components in the juice that are shared by other juices. On a more positive side, it did demonstrate the benefit of a balanced diet, regular physical activity and improvements in performance, perhaps as a result of extra nutrients and energy provided by the juice.

Time to juice up? Nope, just time to start opening your eyes a bit wider when you see headlines touting the amazing benefits of a quick fix. Rule number 1? There are no quick fixes.

Wednesday bubble: flava flavonoid

Posted by Liz on Jun 24, 2009 in diet | 5 comments

With the acai berry craze hitting its peak, I thought it was high time to devote a post to flavonoids (compounds found in plants, fruits and beverages that have been shown to have antioxidant and anti-inflammatory properties) — namely, those found in berries.

Yes, berries, This sounded a bit preposterous until I dug a bit deeper and located a current review in Maturitas, suggesting that berry flavonoids might be important for long-term health in menopausal women. However, researchers still can’t define the most important details, for example:

• berry type
• preparation
• regimen

The amount of berry flavonoid that becomes available and used by the body after eating also varies by individual make up and by the different types of flavonoids.

All of these factors are critical to designing a strategy that will yield the maximum health benefit. Nevertheless, evidence from clinical studies suggests the following:

• The addition of berries to the diet can reduce the risk of heart disease by halting the inflammatory process, eliminating free radicals (which can harm the structure of cells), decreasing blood pressure, inhibiting the gathering of platelets (which can lead to clogged arteries) and increasing high density lipoproteins (HDL, good cholesterol)/ reducing low-density lipoproteins (LDL, bad cholesterol). Data points to cranberry juice, wild blueberries, bilberries, blackcurrant or strawberry puree, and chokeberry or raspberry juices.

• Cancer prevention. Note that this has been controversial since increased consumption of dietary fruits and vegetables and not just berries, have been shown to impact certain cancers such as esophogeal cancer. In the small studies that the researchers cite, cranberry juice and freeze dried black raspberry have been shown to control signaling that promotes the proliferation of cancer cells.

• Age-related declines in motor skills, learning and memory impairment, specifically, those linked to a decline in the body’s ability to fight circulating free oxygen radicals that can damage cells. Evidence for these benefits are primarily derived from animal and not human studies, and concentrate on strawberries, blueberries and cranberries.

The researchers caution that it’s impossible to define how much of a single berry or combination of berries might help in disease prevention. Hence, it’s too early to make any definitive claims about berry consumption. However, they do emphasize that to date, research supports the importance of berries as part of a healthy, balanced diet for menopausal women.

Personally, I love berries and health benefits or not, I plan to eat as much of them as I can get my hands on this summer.