Don’t put all your eggs in one basket!

Posted by Liz on Sep 5, 2014 in menopause | 0 comments

Back in 2010 I wrote a piece about a woman’s egg supply and its role in predicting when menopause may start. There’s some new information to add to the story so thought I’d rerun the piece with a few highlights.

So eggs and baskets. What, pray tell, do they have to do with menopause? Let’s break it down, step by step (or, year by year, as the case may be). The bottom line is that roughly 69% of the total reserve of eggs that a woman has and how that varies throughout her lifetime can be determined by age alone.

While still in the womb, a female will develop several million eggs. Up until age 14, the eggs will continue to increase in number, accelerate around puberty (i.e. ages 9 through and then the reserve steadily declines until menopause (around age 50 or 51).

Using computer modeling of data taken from about 325 women, researchers determined that by the age of 30, 95% of women will only have 12% of their egg reserves remaining. By age 40, only 3% remain.  What’s more, age remains the primary influencer of the number of eggs up until about age 25. Then as a women grows older, other factors, including smoking, body mass index, stress and previous pregnancies start to play more important roles.

Back to the menopause component. The majority of readers of this blog are of the age where pregnancy is no longer a consideration an the number of eggs in reserve, pretty irrelevant. However, by considering and mapping how the ovarian reserve of eggs is established and then diminished in the first place, researchers hope to be better able to predict when menopause will start individual women. This strategy compliments the anti-Mullerian hormone blood test (check out information on that here) and closely follows the way that scientists used the blood test to predict menopause.

However, geeky science aside, by having a better idea of when menopause will start, you may be able to take appropriate steps in a timely fashion to both stave off vasomotor symptoms such as hot flashes and night sweats and maintain body weight and physical health. What’s more, imagine the possibilities in terms of mood swings and depression. The potential rewards are endless.

According to the researchers, they might also be able to predict which women treated for cancer are at highest risk for early menopause as the result of treatment. Since many of these women are young, this might provide opportunities for proactive family planning.

And finally, by measuring ovarian volumes, a key factor in the computer modeling, researchers believe that they may be able to predict young women who are at risk for developing premature loss of their ovarian function, a common side effect of cancer treatment. The benefit here is that it may be a way to help these young women preserve their eggs early for later fertility efforts.

So, all those eggs in one basket? You might not be able to control how many but you may be able to control certain outcomes. Nice!